m6A  FTO  hm6Af6AA\text{m}^6\text{A} \xrightarrow{\;\text{FTO}\;} \text{hm}^6\text{A} \to \text{f}\,^6\text{A} \to \text{A}
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Biology

The Eraser Hypothesis: Epitranscriptomic Modulation of Synaptic Plasticity Under Metabolic Stress

Memory requires building new proteins at the synapses that fire during learning. A chemical tag on messenger RNA controls which proteins get built, and the enzyme FTO erases the tag. Metabolic stress makes FTO too aggressive, so fewer proteins are built and memory suffers. This paper proposes a way to slow FTO without shutting it off.

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Astronomy

Plate-Solving an iPhone Photograph

Recovering the celestial coordinates of a smartphone photograph via EXIF-assisted plate-solving, Hipparcos catalog matching, and WISE/GALEX cross-archive imaging.

G(t)=(0,)eρtM(dρ)G(t) = \int_{(0,\infty)} e^{-\rho t} M(\mathrm{d}\rho)
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Mathematics

Passivity-Preserving Model Reduction for Transient Cross-Impact

When you trade one stock, it ripples through the prices of other stocks, and that ripple fades over time. This paper finds a way to compress that complex, high-dimensional ripple effect into a small, tractable model that is guaranteed to never create fake arbitrage.

Philosophy

On the Beauty of Contradiction in Christ

Even if Christianity were only a legend, it still inspired Bach's St Matthew Passion, Europe's cathedrals, and Kepler's laws. This essay explores the strange beauty of a facade that produces real masterpieces, and asks whether that paradox itself is meaningful.

L=argmaxφF{Gˉ(φ)λ(φ)}\mathcal{L}^\star = \arg\max_{\varphi \in \mathcal{F}} \left\{ \bar{G}(\varphi) - \lambda\, \ell(\varphi) \right\}
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Mathematics

The Cross-Universe Symbolic Regression Tournament: Survival of the Fittest Laws

Imagine letting a computer guess equations that fit your data, then making those guesses fight for survival across totally different datasets. Like natural selection, but for math formulas. The last equation standing is your best bet at the real underlying law.